Genetic Ancestry for Sleep Research

Mapping human genetic ancestry.

The human genome is a mosaic with respect to its evolutionary history. Based on a phylogenetic analysis of 23,210 DNA sequence alignments from human, chimpanzee, gorilla, orangutan, and rhesus, we present a map of human genetic ancestry. For about 23% of our genome, we share no immediate genetic ancestry with our closest living relative, the chimpanzee. This encompasses genes and exons to the s...

Influence of Genetic Ancestry on the Risk for Obstructive Sleep Apnoea Syndrome

Genealogical and Genetic Ancestry for k Loci

The genealogical ancestors to an individual are the the individuals that can be reached by a string of operators mother/father to that individual, like motherfatherfather. Within that set are the individuals, that has genetic material that was transmitted to the present individual. Genetic ancestry is in general given more attention as that is a component in genetic analysis and mapping, while ...

Different differences: the use of 'genetic ancestry' versus race in biomedical human genetic research.

This article presents findings from our ethnographic research on biomedical scientists' studies of human genetic variation and common complex disease. We examine the socio-material work involved in genome-wide association studies (GWAS) and discuss whether, how, and when notions of race and ethnicity are or are not used. We analyze how researchers produce simultaneously different kinds of popul...

To what extent does genealogical ancestry imply genetic ancestry?

Recent statistical and computational analyses have shown that a genealogical most recent common ancestor (MRCA) may have lived in the recent past [Chang, J.T., 1999. Recent common ancestors of all present-day individuals. Adv. Appl. Probab. 31, 1002-1026. 1027-1038; Rohde, D.L.T., Olson, S., Chang, J.T., 2004. Modelling the recent common ancestry of all living humans. Nature 431, 562-566]. Howe...